Physiological implications of biased signaling at histamine H2 receptors.

Physiological implications of biased signaling at histamine H2 receptors.

Histamine mediates numerous functions acting through its four receptor subtypes all belonging to the large family of seven transmembrane G-protein coupled receptors (GPCRs). In particular, histamine H2 receptor (H2R) is mainly involved in gastric acid production, becoming a classic pharmacological t...

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Bibliographic Details
Main Authors: Natalia eAlonso, Carlos Daniel Zappia, Maia eCabrera, Carlos Alberto Davio, Carina eShayo, Federico eMonczor, Natalia Cristina Fernandez
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Pharmacology
Subjects:
Histamine
ERK
biased agonism
HDC
GPCR internalization
7TMR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00045/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00045/full

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