Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment

Induced PTF1a expression in pancreatic ductal adenocarcinoma cells activates acinar gene networks, reduces tumorigenic properties, and sensitizes cells to gemcitabine treatment

Pancreatic acinar cells synthesize, package, and secrete digestive enzymes into the duodenum to aid in nutrient absorption and meet metabolic demands. When exposed to cellular stresses and insults, acinar cells undergo a dedifferentiation process termed acinar–ductal metaplasia (ADM). ADM lesions wi...

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Bibliographic Details
Main Authors: Brad L. Jakubison, Patrick G. Schweickert, Sarah E. Moser, Yi Yang, Hongyu Gao, Kathleen Scully, Pamela Itkin‐Ansari, Yunlong Liu, Stephen F. Konieczny
Format: Article
Language:English
Published: Wiley 2018-06-01
Series:Molecular Oncology
Subjects:
ABC transporters
bHLH
exocrine pancreas
MIST1
PDAC
transcription
Online Access:https://doi.org/10.1002/1878-0261.12314

Internet

https://doi.org/10.1002/1878-0261.12314

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