Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-β/Smad2/3 Pathway

Polyporus Polysaccharide Ameliorates Bleomycin-Induced Pulmonary Fibrosis by Suppressing Myofibroblast Differentiation via TGF-β/Smad2/3 Pathway

Pulmonary fibrosis is a major cause of morbidity and mortality in systemic sclerosis (SSc) with no effective medication. Polyporus polysaccharide (PPS), extracted from Chinese herbs, has immune regulation, anticancer, antioxidant and antiinflammatory activities. This study aims to investigate antifi...

Full description

Bibliographic Details
Main Authors: Jintao Jiang, Fang Wang, Aishu Luo, Shiyu Lin, Xiaoke Feng, Wei Yan, Yumeng Shi, Qian Zhang, Xin Gu, Guoliang Cui, Jianan Wang, Lei Wang, Qiande Zhang, Wenfeng Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
polyporus polysaccharide
pulmonary fibrosis
systemic sclerosis
myofibroblast
TGF-β/Smad2/3
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00767/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00767/full

Similar Items