HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Abstract Background Heat shock protein 90 (HSP90) functions as a well-known onco-protein to regulate protein conformation, stability and degradation. Pyruvate kinase M2 (PKM2), a critical regulator of the metabolism, growth and metastasis of cancer cells, has been confirmed to be overexpressed in va...

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Bibliographic Details
Main Authors: Qiuran Xu, Jianfeng Tu, Changwei Dou, Jun Zhang, Liu Yang, Xin Liu, Kefeng Lei, Zhikui Liu, Yufeng Wang, Lijie Li, Hangxing Bao, Jiahui Wang, Kangsheng Tu
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Molecular Cancer
Subjects:
Hepatocellular carcinoma
HSP90
PKM2
Glycolysis
Growth
Online Access:http://link.springer.com/article/10.1186/s12943-017-0748-y

Internet

http://link.springer.com/article/10.1186/s12943-017-0748-y

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