Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer’s disease

Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer’s disease

Abstract Background There is accumulating evidence that synaptic loss precedes neuronal loss and correlates best with impaired memory formation in Alzheimer’s disease (AD). Cerebrospinal fluid (CSF) synaptosomal-associated protein 25 (SNAP-25) is a newly discovered marker indicating synaptic damage....

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Bibliographic Details
Main Authors: Hua Zhang, Joseph Therriault, Min Su Kang, Kok Pin Ng, Tharick A. Pascoal, Pedro Rosa-Neto, Serge Gauthier, the Alzheimer’s Disease Neuroimaging Initiative
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Amyloid-β
Synaptic loss
Synaptosomal-associated protein 25
Online Access:http://link.springer.com/article/10.1186/s13195-018-0407-6

Internet

http://link.springer.com/article/10.1186/s13195-018-0407-6

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