Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model

Alleviation of exhaustion-induced immunosuppression and sepsis by immune checkpoint blockers sequentially administered with antibiotics—analysis of a new mathematical model

Abstract Background Sepsis-associated immune dysregulation, involving hyper-inflammation and immunosuppression, is common in intensive care patients, often leading to multiple organ dysfunction and death. The aim of this study was to identify the main driving force underlying immunosuppression in se...

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Bibliographic Details
Main Authors: Avi Gillis, Michael Beil, Karin Halevi-Tobias, Peter Vernon van Heerden, Sigal Sviri, Zvia Agur
Format: Article
Language:English
Published: SpringerOpen 2019-06-01
Series:Intensive Care Medicine Experimental
Subjects:
Simulations
Dynamic model
T lymphocyte exhaustion
Immunosuppression
Checkpoint blockers
Hyper-inflammation
Online Access:http://link.springer.com/article/10.1186/s40635-019-0260-3

Internet

http://link.springer.com/article/10.1186/s40635-019-0260-3

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