Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies

The deposition of misfolded β-sheet enriched amyloid protein is a shared feature of many neurodegenerative diseases. Recent studies demonstrated the existence of conformationally diverse strains as a common property for multiple amyloidogenic proteins including α-Synuclein (α-Syn). α-Syn is misfolde...

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Bibliographic Details
Main Authors: Chao Peng, Ronald J. Gathagan, Virginia M.-Y. Lee
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996117301705