Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice

Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice

Abstract Prion diseases are fatal, infectious, and incurable neurodegenerative disorders caused by misfolding of the cellular prion protein (PrPC) into the infectious isoform (PrPSc). In humans, there are sporadic, genetic and infectious etiologies, with sporadic Creutzfeldt-Jakob disease (sCJD) bei...

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Bibliographic Details
Main Authors: Tahir Ali, Samia Hannaoui, Satish Nemani, Waqas Tahir, Irina Zemlyankina, Pearl Cherry, Su Yeon Shim, Valerie Sim, Hermann M. Schaetzl, Sabine Gilch
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Acta Neuropathologica Communications
Online Access:https://doi.org/10.1186/s40478-021-01162-1

Internet

https://doi.org/10.1186/s40478-021-01162-1

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