Pharmacological Manipulation of DNA Methylation in Adult Female Rats Normalizes Behavioral Consequences of Early-Life Maltreatment

Pharmacological Manipulation of DNA Methylation in Adult Female Rats Normalizes Behavioral Consequences of Early-Life Maltreatment

Exposure to adversity early in development alters brain and behavioral trajectories. Data continue to accumulate that epigenetic mechanisms are a mediating factor between early-life adversity and adult behavioral phenotypes. Previous work from our laboratory has shown that female Long-Evans rats exp...

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Bibliographic Details
Main Authors: Samantha M. Keller, Tiffany S. Doherty, Tania L. Roth
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
epigenetics
DNMT
DNA methylation
development
maltreatment
early-life stress
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2018.00126/full

Internet

https://www.frontiersin.org/article/10.3389/fnbeh.2018.00126/full

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