Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential.

Hypoxia induces EMT in low and highly aggressive pancreatic tumor cells but only cells with cancer stem cell characteristics acquire pronounced migratory potential.

Tumor hypoxia induces epithelial-mesenchymal transition (EMT), which induces invasion and metastasis, and is linked to cancer stem cells (CSCs). Whether EMT generates CSCs de novo, enhances migration of existing CSCs or both is unclear. We examined patient tissue of pancreatic ductal adenocarcinoma...

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Bibliographic Details
Main Authors: Alexei V Salnikov, Li Liu, Mitja Platen, Jury Gladkich, Olga Salnikova, Eduard Ryschich, Jürgen Mattern, Gerhard Moldenhauer, Jens Werner, Peter Schemmer, Markus W Büchler, Ingrid Herr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3458836?pdf=render

Internet

http://europepmc.org/articles/PMC3458836?pdf=render

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