Metabolomics Fingerprint Induced by the Intranigral Inoculation of Exogenous Human Alpha-Synuclein Oligomers in a Rat Model of Parkinson’s Disease

Metabolomics Fingerprint Induced by the Intranigral Inoculation of Exogenous Human Alpha-Synuclein Oligomers in a Rat Model of Parkinson’s Disease

Parkinson’s disease (PD) is considered a synucleinopathy because of the intraneuronal accumulation of aggregated α-synuclein (αSyn). Recent evidence points to soluble αSyn-oligomers (αSynO) as the main cytotoxic species responsible for cell death. Given the pivotal role of αSyn in PD, αSyn-based mod...

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Bibliographic Details
Main Authors: Federica Murgia, Luigi Atzori, Ezio Carboni, Maria Laura Santoru, Aran Hendren, Augusta Pisanu, Pierluigi Caboni, Laura Boi, Giuliana Fusco, Anna R. Carta
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
α-synuclein oligomers
Parkinson model
metabolomics
mesencephalic tissue
serum
gas chromatography mass spectrometry
Online Access:https://www.mdpi.com/1422-0067/21/18/6745

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https://www.mdpi.com/1422-0067/21/18/6745

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