Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model

Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model

Abstract Background Interleukin 23 is a critical cytokine in the pathogenesis of multiple sclerosis. But the local impact of interleukin 23 on the course of neuroinflammation is still not well defined. To further characterize the effect of interleukin 23 on CNS inflammation, we recently described a...

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Bibliographic Details
Main Authors: Louisa Nitsch, Simon Petzinna, Julian Zimmermann, Linda Schneider, Marius Krauthausen, Michael T. Heneka, Daniel R. Getts, Albert Becker, Marcus Müller
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Neuroinflammation
Subjects:
EAE
IL-23
Neuroinflammation
B cells
CNS
Online Access:https://doi.org/10.1186/s12974-021-02140-z

Internet

https://doi.org/10.1186/s12974-021-02140-z

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