Astrocyte-specific expression of interleukin 23 leads to an aggravated phenotype and enhanced inflammatory response with B cell accumulation in the EAE model
Abstract Background Interleukin 23 is a critical cytokine in the pathogenesis of multiple sclerosis. But the local impact of interleukin 23 on the course of neuroinflammation is still not well defined. To further characterize the effect of interleukin 23 on CNS inflammation, we recently described a...
Main Authors: | Louisa Nitsch, Simon Petzinna, Julian Zimmermann, Linda Schneider, Marius Krauthausen, Michael T. Heneka, Daniel R. Getts, Albert Becker, Marcus Müller |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-04-01
|
Series: | Journal of Neuroinflammation |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12974-021-02140-z |
Similar Items
-
T cell mediated pathogenesis in EAE: Molecular mechanisms
by: Florian C Kurschus
Published: (2015-06-01) -
Microglia-Derived Interleukin 23: A Crucial Cytokine in Alzheimer's Disease?
by: Louisa Nitsch, et al.
Published: (2021-04-01) -
MANF Is Neuroprotective in Early Stages of EAE, and Elevated in Spinal White Matter by Treatment With Dexamethasone
by: Jinhan Nam, et al.
Published: (2021-07-01) -
Astrocytic IL-6 Influences the Clinical Symptoms of EAE in Mice
by: Maria Erta, et al.
Published: (2016-05-01) -
IL-10-differentiated dendritic cells treatment for Experimental Autoimmune Encephalomyelitis (EAE), a model of human Multiple Sclerosis
by: Xie, Siyuan
Published: (2010)