Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2

Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2

Vascular endothelial growth factor-A (VEGF-A) is a key mediator of angiogenesis, signalling via the class IV tyrosine kinase receptor family of VEGF Receptors (VEGFRs). Although VEGF-A ligands bind to both VEGFR1 and VEGFR2, they primarily signal via VEGFR2 leading to endothelial cell proliferation,...

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Bibliographic Details
Main Authors: Chloe J. Peach, Viviane W. Mignone, Maria Augusta Arruda, Diana C. Alcobia, Stephen J. Hill, Laura E. Kilpatrick, Jeanette Woolard
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
angiogenesis
endothelial cells
blood vessel
splicing
receptor tyrosine kinase inhibitors
Online Access:http://www.mdpi.com/1422-0067/19/4/1264

Internet

http://www.mdpi.com/1422-0067/19/4/1264

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