Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve

Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve

The optic nerve crush injury is a well-accepted model to study the mechanisms of axonal regeneration after trauma in the CNS. The infection of retinal ganglion cells (RGCs) with an adeno-associated virus serotype 2 — ciliary neurotrophic factor (AAV2.CNTF) was previously shown to stimulate axonal re...

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Bibliographic Details
Main Authors: Vincent Pernet, Sandrine Joly, Deniz Dalkara, Noémie Jordi, Olivia Schwarz, Franziska Christ, David V. Schaffer, John G. Flannery, Martin E. Schwab
Format: Article
Language:English
Published: Elsevier 2013-03-01
Series:Neurobiology of Disease
Subjects:
Axonal regeneration
Adeno-associated virus
Retinal ganglion cells
Neuronal survival
Gene therapy
Ciliary neurotrophic factor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112003749

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http://www.sciencedirect.com/science/article/pii/S0969996112003749

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