Antitumor Potential of Extracellular Vesicles Released by Genetically Modified Murine Colon Carcinoma Cells With Overexpression of Interleukin-12 and shRNA for TGF-β1

Antitumor Potential of Extracellular Vesicles Released by Genetically Modified Murine Colon Carcinoma Cells With Overexpression of Interleukin-12 and shRNA for TGF-β1

Recent developments demonstrate that tumor-derived extracellular vesicles (EVs) could become a highly effective tool for delivery of antitumor factors. The main objective of the study was to determine whether EVs secreted by MC38 colon carcinoma cells genetically engineered for overproduction of int...

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Bibliographic Details
Main Authors: Joanna Rossowska, Natalia Anger, Katarzyna Wegierek, Agnieszka Szczygieł, Jagoda Mierzejewska, Magdalena Milczarek, Bożena Szermer-Olearnik, Elżbieta Pajtasz-Piasecka
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
tumor-derived exosomes
tumor-derived microvesicles
dendritic cells
interleukin 12
TGF-β1 silencing
lentivectors
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00211/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00211/full

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