Nuclear IHC enumeration: A digital phantom to evaluate the performance of automated algorithms in digital pathology.

Automatic and accurate detection of positive and negative nuclei from images of immunostained tissue biopsies is critical to the success of digital pathology. The evaluation of most nuclei detection algorithms relies on manually generated ground truth prepared by pathologists, which is unfortunately...

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Main Authors: Muhammad Khalid Khan Niazi, Fazly Salleh Abas, Caglar Senaras, Michael Pennell, Berkman Sahiner, Weijie Chen, John Opfer, Robert Hasserjian, Abner Louissaint, Arwa Shana'ah, Gerard Lozanski, Metin N Gurcan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5944932?pdf=render