The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy

The Ionotropic P2X4 Receptor has Unique Properties in the Heart by Mediating the Negative Chronotropic Effect of ATP While Increasing the Ventricular Inotropy

Background: Mounting evidence indicate that reducing the sinoatrial node (SAN) activity may be a useful therapeutic strategy to control of heart failure. Purines, like ATP and its metabolite adenosine, consistently reduce the SAN spontaneous activity leading to negative cardiac chronotropy, with var...

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Bibliographic Details
Main Authors: Bruno Bragança, Sílvia Nogueira-Marques, Fátima Ferreirinha, Ana Patrícia Fontes-Sousa, Paulo Correia-de-Sá
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
ATP
P2X4 receptor
Na+/Ca2+ exchanger
sinoartrial node
spontaneously beating atria
paced right ventricle
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01103/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01103/full

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