Abnormal Thyroid Hormone Status Differentially Affects Bone Mass Accrual and Bone Strength in C3H/HeJ Mice: A Mouse Model of Type I Deiodinase Deficiency

Abnormal Thyroid Hormone Status Differentially Affects Bone Mass Accrual and Bone Strength in C3H/HeJ Mice: A Mouse Model of Type I Deiodinase Deficiency

C3H/HeJ (C3H) mice are deficient of type I deiodinase (D1), an enzyme that activates thyroid hormone (TH), converting thyroxine (T4) to triiodothyronine (T3). Nevertheless, C3H mice present normal serum T3 and a gross euthyroid phenotype. To investigate if a global D1 deficiency interferes in the TH...

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Bibliographic Details
Main Authors: Clarissa R. Zaitune, Tatiana L. Fonseca, Luciane P. Capelo, Fatima R. Freitas, Eduardo H. Beber, José M. Dora, Charles C. Wang, Manuela Miranda-Rodrigues, Keico O. Nonaka, Ana L. Maia, Cecilia H. A. Gouveia
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Endocrinology
Subjects:
thyroid hormone
iodothyronine deiodinases
bone mass accrual
bone growth
C3H/HeJ and C57BL/6J
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00300/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00300/full

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