daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival

daf-16/FoxO promotes gluconeogenesis and trehalose synthesis during starvation to support survival

daf-16/FoxO is required to survive starvation in Caenorhabditis elegans, but how daf-16IFoxO promotes starvation resistance is unclear. We show that daf-16/FoxO restructures carbohydrate metabolism by driving carbon flux through the glyoxylate shunt and gluconeogenesis and into synthesis of trehalos...

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Bibliographic Details
Main Authors: Jonathan D Hibshman, Alexander E Doan, Brad T Moore, Rebecca EW Kaplan, Anthony Hung, Amy K Webster, Dhaval P Bhatt, Rojin Chitrakar, Matthew D Hirschey, L Ryan Baugh
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-10-01
Series:eLife
Subjects:
starvation
insulin
trehalose
stress response
gluconeogenesis
glyoxylate
Online Access:https://elifesciences.org/articles/30057

Internet

https://elifesciences.org/articles/30057

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