Vascular NRP2 triggers PNET angiogenesis by activating the SSH1-cofilin axis

Vascular NRP2 triggers PNET angiogenesis by activating the SSH1-cofilin axis

Abstract Background Angiogenesis is a critical step in the growth of pancreatic neuroendocrine tumors (PNETs) and may be a selective target for PNET therapy. However, PNETs are robustly resistant to current anti-angiogenic therapies that primarily target the VEGFR pathway. Thus, the mechanism of PNE...

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Bibliographic Details
Main Authors: Xi Luo, Jiang-yi He, Jie Xu, Shao-yi Hu, Bang-hui Mo, Qiu-xia Shu, Can Chen, Yu-zhu Gong, Xiao-long Zhao, Gan-feng Xie, Song-tao Yu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Cell & Bioscience
Subjects:
Neuropilin 2
Angiogenesis
SSH1
Cofilin
Pancreatic neuroendocrine tumor
Online Access:http://link.springer.com/article/10.1186/s13578-020-00472-6

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http://link.springer.com/article/10.1186/s13578-020-00472-6

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