Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development

Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development

Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN have mostly utilized patient fibroblasts and...

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Bibliographic Details
Main Authors: Heidi R Fuller, Berhan eMandefro, Sally L Shirran, Andrew R Gross, Anjoscha Samija Kaus, Catherine H Botting, Glenn E Morris, Dhruv eSareen
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Induced Pluripotent Stem Cells
Proteomics
motor neuron
SMA
IPSC
spinal muscular atrophy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00506/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00506/full

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