Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2

Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2

The Hedgehog (Hh) signaling pathway plays a crucial role in normal embryonic development and adult tissue homeostasis. On the other end, dysregulated Hh signaling triggers a prolonged mitogenic response that may prompt abnormal cell proliferation, favoring tumorigenesis. Indeed, about 30% of medullo...

Full description

Bibliographic Details
Main Authors: Annapaola Angrisani, Annamaria Di Fiore, Claudia Augusta Di Trani, Simone Fonte, Marialaura Petroni, Ludovica Lospinoso Severini, Fabio Bordin, Laura Belloni, Elisabetta Ferretti, Gianluca Canettieri, Marta Moretti, Enrico De Smaele
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
KCASH2
KCTD21
Hedgehog
Sp1
p53
medulloblastoma cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.638508/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.638508/full

Similar Items