The power of regional heritability analysis for rare and common variant detection: simulations and application to eye biometrical traits

The power of regional heritability analysis for rare and common variant detection: simulations and application to eye biometrical traits

Genome-wide association studies (GWAS) have provided valuable insights into the genetic basis of complex traits. However, they have explained relatively little trait heritability. Recently, we proposed a new analytical approach called regional heritability mapping (RHM) that captures more of the mis...

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Bibliographic Details
Main Authors: Yoshinobu eUemoto, Ricardo ePong-Wong, Pau eNavarro, Veronique eVitart, Caroline eHayward, James F. Wilson, Igor eRudan, Harry eCampbell, Nicholas D. Hastie, Alan F. Wright, Chris S. Haley
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Genetics
Subjects:
Axial Length, Eye
Mapping
genome wide association study
heritability
Spherical equivalent refraction
central corneal thickness
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00232/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00232/full

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