A Transcription Regulatory Sequence in the 5′ Untranslated Region of SARS-CoV-2 Is Vital for Virus Replication with an Altered Evolutionary Pattern against Human Inhibitory MicroRNAs

A Transcription Regulatory Sequence in the 5′ Untranslated Region of SARS-CoV-2 Is Vital for Virus Replication with an Altered Evolutionary Pattern against Human Inhibitory MicroRNAs

Our knowledge of the evolution and the role of untranslated region (UTR) in SARS-CoV-2 pathogenicity is very limited. Leader sequence, originated from UTR, is found at the 5′ ends of all encoded SARS-CoV-2 transcripts, highlighting its importance. Here, evolution of leader sequence was compared betw...

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Bibliographic Details
Main Authors: Manijeh Mohammadi-Dehcheshmeh, Sadrollah Molaei Moghbeli, Samira Rahimirad, Ibrahim O. Alanazi, Zafer Saad Al Shehri, Esmaeil Ebrahimie
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cells
Subjects:
COVID-19
biomarker
drug repurposing
microRNA
SARS-CoV-2 replication
microRNA vaccine
Online Access:https://www.mdpi.com/2073-4409/10/2/319

Internet

https://www.mdpi.com/2073-4409/10/2/319

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