A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA<sub>A</sub> Receptor

A Structure-Activity Relationship Comparison of Imidazodiazepines Binding at Kappa, Mu, and Delta Opioid Receptors and the GABA<sub>A</sub> Receptor

Analgesic and anti-inflammatory properties mediated by the κ opioid receptor (KOR) have been reported for oxadiazole imidazodiazepines. Affinities determined by radioligand competition assays of more than seventy imidazodiazepines using cell homogenates from HEK293 cells that overexpress KOR, µ opio...

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Bibliographic Details
Main Authors: Guanguan Li, Amanda N. Nieman, Md Yeunus Mian, Nicolas M. Zahn, Brandon N. Mikulsky, Michael M. Poe, Kashi R. Methuku, Yongfeng Liu, James M. Cook, Douglas C. Stafford, Leggy A. Arnold
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Molecules
Subjects:
opioid receptor
imidazodiazepine
GABA<sub>A</sub> receptor
Online Access:https://www.mdpi.com/1420-3049/25/17/3864

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https://www.mdpi.com/1420-3049/25/17/3864

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