A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes[S]

A putative role of micro RNA in regulation of cholesterol 7α-hydroxylase expression in human hepatocytes[S]

Cholesterol 7α-hydroxylase (CYP7A1) plays a critical role in regulation of bile acid synthesis in the liver. CYP7A1 mRNAs have very short half-lives, and bile acids destabilize CYP7A1 mRNA via the 3′-untranslated region (3′-UTR). However, the underlying mechanism of translational regulation of CYP7A...

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Bibliographic Details
Main Authors: Kwang-Hoon Song, Tiangang Li, Erika Owsley, John Y.L. Chiang
Format: Article
Language:English
Published: Elsevier 2010-08-01
Series:Journal of Lipid Research
Subjects:
bile acid synthesis
FGF19
nuclear receptors
FXR
lipid metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520370589

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http://www.sciencedirect.com/science/article/pii/S0022227520370589

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