Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues

Species differences in phenobarbital-mediated UGT gene induction in rat and human liver microtissues

Species differences in hepatic metabolism of thyroxine (T4) by uridine diphosphate glucuronosyl transferase (UGT) and susceptibility to thyroid hormone imbalance could underlie differences in thyroid carcinogenesis caused by hepatic enzyme inducers in rats and humans. To investigate this hypothesis...

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Bibliographic Details
Main Authors: Simon Plummer, Bobby Beaumont, Matthew Elcombe, Stephanie Wallace, Jayne Wright, Elizabeth F Mcinnes, Richard A Currie, David Cowie
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Toxicology Reports
Subjects:
Thyroid carcinogenesis
Liver microtissues
Uridine glucuronosyltransferase
Genomics
Cross species risk assessment
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750020304649

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http://www.sciencedirect.com/science/article/pii/S2214750020304649

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