Equivalent T cell epitope promiscuity in ecologically diverse human pathogens.

The HLA (human leukocyte antigen) molecules that present pathogen-derived epitopes to T cells are highly diverse. Correspondingly, many pathogens such as HIV evolve epitope variants in order to evade immune recognition. In contrast, another persistent human pathogen, Mycobacterium tuberculosis, has...

Full description

Bibliographic Details
Main Authors: Kirsten E Wiens, Harish Swaminathan, Richard Copin, Desmond S Lun, Joel D Ernst
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3739752?pdf=render