A novel substitution matrix fitted to the compositional bias in Mollicutes improves the prediction of homologous relationships

<p>Abstract</p> <p>Background</p> <p>Substitution matrices are key parameters for the alignment of two protein sequences, and consequently for most comparative genomics studies. The composition of biological sequences can vary importantly between species and groups of s...

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Bibliographic Details
Main Authors: Lemaitre Claire, Barré Aurélien, Citti Christine, Tardy Florence, Thiaucourt François, Sirand-Pugnet Pascal, Thébault Patricia
Format: Article
Language:English
Published: BMC 2011-11-01
Series:BMC Bioinformatics
Online Access:http://www.biomedcentral.com/1471-2105/12/457