NF-κB Activation Exacerbates, but Is not Required for Murine Bmpr2-Related Pulmonary Hypertension

NF-κB Activation Exacerbates, but Is not Required for Murine Bmpr2-Related Pulmonary Hypertension

Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation. Methods and Results: Electrophoretic mobility shift assay for nuclear extracts in Bmpr2R899X mouse lung an...

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Bibliographic Details
Main Authors: Megha Talati, Haitham Mutlak, Kirk B. Lane, Wei Han, Anna Hemnes, Outi Mutlak, Tom Blackwell, Rinat Zaynagetdinov, Timothy S. Blackwell, James West
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Diseases
Subjects:
pulmonary arterial hypertension
bone morphogenic protein receptor type 2
NF-κB
inflammation
Online Access:http://www.mdpi.com/2079-9721/2/2/148

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http://www.mdpi.com/2079-9721/2/2/148

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