Transplantation of neural cells derived from retinoic acid-treated cynomolgus monkey embryonic stem cells successfully improved motor function of hemiplegic mice with experimental brain injury

Transplantation of neural cells derived from retinoic acid-treated cynomolgus monkey embryonic stem cells successfully improved motor function of hemiplegic mice with experimental brain injury

We induced neural cells by treating cynomolgus monkey embryonic stem (ES) cells with retinoic acid. The treated cells mainly expressed βIIItubulin. They further differentiated into neurons expressing neurofilament middle chain (NFM) in elongated axons. Half of the cells differentiated into Islet1+ m...

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Bibliographic Details
Main Authors: Ritsuko Ikeda, Manae S. Kurokawa, Shunmei Chiba, Hideshi Yoshikawa, Michiko Ide, Mamoru Tadokoro, Shinji Nito, Norio Nakatsuji, Yasushi Kondoh, Ken Nagata, Takuo Hashimoto, Noboru Suzuki
Format: Article
Language:English
Published: Elsevier 2005-10-01
Series:Neurobiology of Disease
Subjects:
Motor neuron
Nonhuman primate
Embryonic stem cells
Hemiplegia
Differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000434

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http://www.sciencedirect.com/science/article/pii/S0969996105000434

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