Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer cells metabolism as tumor microenvironment is affected by oxidative stress. This event triggers adequate cellular response...

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Bibliographic Details
Main Authors: Natalia Siwecka, Wioletta Rozpędek, Dariusz Pytel, Adam Wawrzynkiewicz, Adam Dziki, Łukasz Dziki, J. Alan Diehl, Ireneusz Majsterek
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
cancer
carcinogenesis
endoplasmic reticulum stress
protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)
unfolded protein response
apoptosis
reactive oxygen species
cancer treatment
Online Access:https://www.mdpi.com/1422-0067/20/18/4354

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https://www.mdpi.com/1422-0067/20/18/4354

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