Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes

Reductive Evolution and Diversification of C5-Uracil Methylation in the Nucleic Acids of Mollicutes

The C5-methylation of uracil to form 5-methyluracil (m<sup>5</sup>U) is a ubiquitous base modification of nucleic acids. Four enzyme families have converged to catalyze this methylation using different chemical solutions. Here, we investigate the evolution of 5-methyluracil synthase fami...

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Bibliographic Details
Main Authors: Pascal Sirand-Pugnet, Damien Brégeon, Laure Béven, Catherine Goyenvalle, Alain Blanchard, Simon Rose, Henri Grosjean, Stephen Douthwaite, Djemel Hamdane, Valérie de Crécy-Lagard
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
base modification
methyltransferases
flavoenzymes
tRNA
rRNA
mycoplasmas
Online Access:https://www.mdpi.com/2218-273X/10/4/587

Internet

https://www.mdpi.com/2218-273X/10/4/587

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