Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats

There is a controversy over the effects of testosterone supplements on dopaminergic function. Both neuroprotective and toxic effects of testosterone supplements are reported. The status of oxidative stress seems to explain the neuroprotective or toxic properties of testosterone. To determine the eff...

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Bibliographic Details
Main Authors: Rui Cui, Yunxiao Kang, Li Wang, Shuangcheng Li, Xiaoming Ji, Wensheng Yan, Guoliang Zhang, Huixian Cui, Geming Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00172/full