Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus

Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus

In addition to tissues such as liver, the plasma membrane sodium-dependent citrate transporter, NaCT (SLC13A5), is highly expressed in brain neurons, but its function is not understood. Loss-of-function mutations in the human SLC13A5 gene have been associated with severe neonatal encephalopathy and...

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Bibliographic Details
Main Authors: Christine Henke, Kathrin Töllner, R. Maarten van Dijk, Nina Miljanovic, Thekla Cordes, Friederike Twele, Sonja Bröer, Vanessa Ziesak, Marco Rohde, Stefanie M. Hauck, Charlotte Vogel, Lisa Welzel, Tina Schumann, Diana M. Willmes, Anica Kurzbach, Nermeen N. El-Agroudy, Stefan R. Bornstein, Susanne A. Schneider, Jens Jordan, Heidrun Potschka, Christian M. Metallo, Rüdiger Köhling, Andreas L. Birkenfeld, Wolfgang Löscher
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Neurobiology of Disease
Subjects:
Epilepsy, NaCT
Proteom
Metabolom
Parahippocampal cortex
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612030293X

Internet

http://www.sciencedirect.com/science/article/pii/S096999612030293X

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