Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions

Inhibition of Phosphodiesterase 3A by Cilostazol Dampens Proinflammatory Platelet Functions

Objective: platelets possess not only haemostatic but also inflammatory properties, which combined are thought to play a detrimental role in thromboinflammatory diseases such as acute coronary syndromes and stroke. Phosphodiesterase (PDE) 3 and -5 inhibitors have demonstrated efficacy in secondary p...

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Bibliographic Details
Main Authors: Daniëlle M. Coenen, Alexandra C. A. Heinzmann, Silvia Oggero, Hugo J. Albers, Magdolna Nagy, Perrine Hagué, Marijke J. E. Kuijpers, Jean-Marie Vanderwinden, Andries D. van der Meer, Mauro Perretti, Rory R. Koenen, Judith M. E. M. Cosemans
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
platelets
thrombosis
vascular inflammation
phosphodiesterase inhibitors
extracellular vesicles
Online Access:https://www.mdpi.com/2073-4409/10/8/1998

Internet

https://www.mdpi.com/2073-4409/10/8/1998

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