Antagonism of peripheral inflammation reduces the severity of status epilepticus

Antagonism of peripheral inflammation reduces the severity of status epilepticus

Status epilepticus (SE) is one of the most serious manifestations of epilepsy. Systemic inflammation and damage of blood-brain barrier (BBB) are etiologic cofactors in the pathogenesis of pilocarpine SE while acute osmotic disruption of the BBB is sufficient to elicit seizures. Whether an inflammato...

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Bibliographic Details
Main Authors: Nicola Marchi, Qingyuan Fan, Chaitali Ghosh, Vincent Fazio, Francesca Bertolini, Giulia Betto, Ayush Batra, Erin Carlton, Imad Najm, Tiziana Granata, Damir Janigro
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Neurobiology of Disease
Subjects:
Blood-brain barrier
Cerebrovascular function
Epilepsy
Inflammation
Anti-inflammatory therapy
New drug targets
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002507

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http://www.sciencedirect.com/science/article/pii/S0969996108002507

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