Amelioratory Effects of Testosterone Propionate on Age-related Renal Fibrosis via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2-ARE Signaling

Amelioratory Effects of Testosterone Propionate on Age-related Renal Fibrosis via Suppression of TGF-β1/Smad Signaling and Activation of Nrf2-ARE Signaling

Abstract Androgen plays a pivotal role in the progression of renal fibrosis. However, whether exogenous androgen treatment to aged male rats can improve the age-related renal fibrosis was not explored. In our study, the changes of morphological structure, renal fibrosis, ultrastructure and renal fun...

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Bibliographic Details
Main Authors: Guoliang Zhang, Yunxiao Kang, Chenming Zhou, Rui Cui, Min Jia, Shen Hu, Xiaoming Ji, Jiayu Yuan, Huixian Cui, Geming Shi
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-29023-3

Internet

https://doi.org/10.1038/s41598-018-29023-3

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