Intracerebroventricular Injection of Metformin Induces Anorexia in Rats

Intracerebroventricular Injection of Metformin Induces Anorexia in Rats

BackgroundMetformin, an oral biguanide insulin-sensitizing agent, is well known to decrease appetite. Although there is evidence that metformin could affect the brain directly, the exact mechanism is not yet known.MethodsTo evaluate whether metformin induces anorexia via the hypothalamus, various co...

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Bibliographic Details
Main Authors: Chang Koo Lee, Yoon Jung Choi, So Young Park, Jong Yeon Kim, Kyu Chang Won, Yong Woon Kim
Format: Article
Language:English
Published: Korean Diabetes Association 2012-08-01
Series:Diabetes & Metabolism Journal
Subjects:
Appetite
Hypothalamus
Metformin
Pro-opiomelanocortin
Online Access:http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-36-293.pdf

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http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-36-293.pdf

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