Itaconate confers tolerance to late NLRP3 inflammasome activation

Itaconate confers tolerance to late NLRP3 inflammasome activation

Summary: Itaconate is a unique regulatory metabolite that is induced upon Toll-like receptor (TLR) stimulation in myeloid cells. Here, we demonstrate major inflammatory tolerance and cell death phenotypes associated with itaconate production in activated macrophages. We show that endogenous itaconat...

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Bibliographic Details
Main Authors: Monika Bambouskova, Lucie Potuckova, Tomas Paulenda, Martina Kerndl, Denis A. Mogilenko, Kate Lizotte, Amanda Swain, Sebastian Hayes, Ryan D. Sheldon, Hyeryun Kim, Unnati Kapadnis, Abigail E. Ellis, Christine Isaguirre, Samantha Burdess, Anwesha Laha, Gaya K. Amarasinghe, Victor Chubukov, Thomas P. Roddy, Michael S. Diamond, Russell G. Jones, Donald M. Simons, Maxim N. Artyomov
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
immunometabolism
macrophages
itaconate
inflammasome
innate immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721000693

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http://www.sciencedirect.com/science/article/pii/S2211124721000693

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