Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice

Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, mainly characterized by motor deficits correlated with progressive dopaminergic neuronal loss in the substantia nigra pars compacta (SN). Necroptosis is a caspase-independent form of regulated cell death mediated by the c...

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Bibliographic Details
Main Authors: Sara R. Oliveira, Pedro A. Dionísio, Maria M. Gaspar, Maria B. T. Ferreira, Catarina A. B. Rodrigues, Rita G. Pereira, Mónica S. Estevão, Maria J. Perry, Rui Moreira, Carlos A. M. Afonso, Joana D. Amaral, Cecília M. P. Rodrigues
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
MPTP
necroptosis
neurodegeneration
Parkinson’s disease
small molecules
Online Access:https://www.mdpi.com/1422-0067/22/10/5289

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https://www.mdpi.com/1422-0067/22/10/5289

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