Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome

Reciprocal Relationship Between HDAC2 and P-Glycoprotein/MRP-1 and Their Role in Steroid Resistance in Childhood Nephrotic Syndrome

Background: Reduced HDACs levels have been reported in steroid resistant chronic obstructive pulmonary disease and bronchial asthma patients. P-glycoprotein (P-gp) over expression in peripheral blood mononuclear cells (PBMCs) has been reported in patients with steroid resistant nephrotic syndrome (N...

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Bibliographic Details
Main Authors: Harshit Singh, Vikas Agarwal, Saurabh Chaturvedi, Durga Prasanna Misra, Akhilesh Kumar Jaiswal, Narayan Prasad
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
P-glycoprotein (P-gp)
multidrug resistance-associated protein 1 (MRP-1)
histone deacetylase2 (HDAC2)
HDAC inhibitor and HDAC stimulator
steroid resistance
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00558/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00558/full

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