Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells

Ovarian Cancers: Genetic Abnormalities, Tumor Heterogeneity and Progression, Clonal Evolution and Cancer Stem Cells

Four main histological subtypes of ovarian cancer exist: serous (the most frequent), endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large majority of ovarian cancers are diagnosed as high-grade serous ovarian cancers (HGS-OvCas). TP53 is the most frequently mutated g...

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Bibliographic Details
Main Authors: Ugo Testa, Eleonora Petrucci, Luca Pasquini, Germana Castelli, Elvira Pelosi
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Medicines
Subjects:
ovarian cancer
genetic alterations
clonal evolution
metastases
chemoresistance
cancer stem cells
Online Access:http://www.mdpi.com/2305-6320/5/1/16

Internet

http://www.mdpi.com/2305-6320/5/1/16

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