Tissue-specific autoregulation of the LXRα gene facilitates induction of apoE in mouse adipose tissue

Tissue-specific autoregulation of the LXRα gene facilitates induction of apoE in mouse adipose tissue

The functions of the liver X receptors (LXRs) are not well documented in adipose tissue. We demonstrate here that expression of the LXRα gene is highly induced in vivo and in vitro in mouse and human adipocytes in the presence of the synthetic LXR agonist T0901317. This autoregulation is caused by a...

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Bibliographic Details
Main Authors: Stine Marie Ulven, Knut Tomas Dalen, Jan-Åke Gustafsson, Hilde I. Nebb
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Journal of Lipid Research
Subjects:
liver X receptor
sterol regulatory element binding protein-1
peroxisome proliferator-activated receptor γ
ATP binding cassette
lipid homeostasis
apolipoprotein E
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520341341

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http://www.sciencedirect.com/science/article/pii/S0022227520341341

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