Small-Molecule-Driven Hepatocyte Differentiation of Human Pluripotent Stem Cells

The differentiation of pluripotent stem cells to hepatocytes is well established, yet current methods suffer from several drawbacks. These include a lack of definition and reproducibility, which in part stems from continued reliance on recombinant growth factors. This has remained a stumbling block...

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Bibliographic Details
Main Authors: Richard Siller, Sebastian Greenhough, Elena Naumovska, Gareth J. Sullivan
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115001010