Opiate dependence induces network state shifts in the limbic system

Among current theories of addiction, hedonic homeostasis dysregulation predicts that the brain reward systems, particularly the mesolimbic dopamine system, switch from a physiological state to a new “set point.” In opiate addiction, evidence show that the dopamine system principal targets, prefronta...

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Bibliographic Details
Main Authors: C. Dejean, T. Boraud, C. Le Moine
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Neurobiology of Disease
Subjects:
LFP
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002064