Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent <i>Escherichia coli</i> ClpP Inhibitors

Identification and Characterization of Approved Drugs and Drug-Like Compounds as Covalent <i>Escherichia coli</i> ClpP Inhibitors

The serine protease Caseinolytic protease subunit P (ClpP) plays an important role for protein homeostasis in bacteria and contributes to various developmental processes, as well as virulence. Therefore, ClpP is considered as a potential drug target in Gram-positive and Gram-negative bacteria. In th...

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Bibliographic Details
Main Authors: Elisa Sassetti, Cristina Durante Cruz, Päivi Tammela, Mathias Winterhalter, Koen Augustyns, Philip Gribbon, Björn Windshügel
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Escherichia coli</i>
ClpP
high-throughput screening
inhibitor
surface plasmon resonance
covalent binding
nitric oxide stress
Online Access:https://www.mdpi.com/1422-0067/20/11/2686

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