Perinatal HIV Infection or Exposure Is Associated With Low N-Acetylaspartate and Glutamate in Basal Ganglia at Age 9 but Not 7 Years

Perinatal HIV Infection or Exposure Is Associated With Low N-Acetylaspartate and Glutamate in Basal Ganglia at Age 9 but Not 7 Years

Abnormalities of the basal ganglia are frequently seen in HIV-infected (HIV+) children despite antiretroviral treatment (ART) initiation during childhood. Assessment of metabolites associated with neuronal integrity or with glial proliferation can present a sensitive description of metabolic events...

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Bibliographic Details
Main Authors: Frances C. Robertson, Martha J. Holmes, Mark F. Cotton, Els Dobbels, Francesca Little, Barbara Laughton, André J. W. van der Kouwe, Ernesta M. Meintjes
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Human Neuroscience
Subjects:
HIV
early ART initiation
NAA
glutamate
magnetic resonance spectroscopy
basal ganglia
Online Access:http://journal.frontiersin.org/article/10.3389/fnhum.2018.00145/full

Internet

http://journal.frontiersin.org/article/10.3389/fnhum.2018.00145/full

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