De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease

De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease

Alterations of lipid metabolism have been frequently associated with Huntington's disease (HD) over the past years. HD is the most common neurodegenerative disorder, with a complex pathogenic profile, typically characterized by progressive striatal and cortical degeneration and associated motor...

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Bibliographic Details
Main Authors: Alba Di Pardo, Abdul Basit, Andrea Armirotti, Enrico Amico, Salvatore Castaldo, Giuseppe Pepe, Federico Marracino, Fabio Buttari, Anna F. Digilio, Vittorio Maglione
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Neuroscience
Subjects:
HD
sphingolipid de novo biosynthesis
dhSph
dhS1P
dhCer
mass spectrometry
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00698/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00698/full

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